mRNA Vaccination and COVID hospitalization and disease severity Messenger RNA (mRNA) COVID-19 vaccines, such as those developed by the companies Moderna and Pfizer-BioNTech, are highly effective for preventing SARS-CoV-2 infections and COVID-19 hospitalizations. However, there have been reports of breakthrough COVID-19 cases, or COVID-19 infections among those who are fully vaccinated. Once hospitalized, patients with COVID-19 can progress to more severe infection, including respiratory failure and death. SARS-CoV-2 infection in vaccinated persons is expected to trigger memory antibody and cellular responses owing to prior vaccination; these immune responses could mitigate disease progression, possibly preventing life-threatening organ failure and death. However, the association between prior vaccination and disease progression to the most severe forms of COVID-19 is not well understood. A recent study published in The Journal of the American Medical Association , inves
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